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Home»Meditation»The 5 Worst Foods for Mental Health |
Meditation

The 5 Worst Foods for Mental Health |

December 2, 2025No Comments12 Mins Read
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You may have heard Hippocrates’ famous quote, “Let food be thy medicine…” And it turns out, he was onto something. Not only is every cell, bone, and molecule within our body shaped by the nutrients we consume, but recent studies highlight the role of a balanced diet in combating depression.

Let’s explore the link between nutrition and mood, and learn the five worst foods for mental health, according to Catherine Gervacio, a registered nutritionist-dietitian and certified exercise nutrition coach at the National Coalition on Health Care.

Understanding the link between diet and mental health

Our dietary choices influence not just our bodily cells, but also the vast population of bacteria in our gut–called the microbiome.

In a world favoring convenient, flavor-rich meals, many of us regularly consume inflammatory foods that compromise our gut health, leading to chronic inflammation. And numerous studies have linked inflammation to depression, among other disorders.

“Chronic inflammation is associated with mental health disorders as it can negatively affect the brain’s function and structure, leading to mood disturbances,” Gervacio says. Conversely, research shows that an anti-inflammatory diet, rich in healthy fats, vitamins, antioxidants, and high-quality protein, can significantly improve mental health issues.

In fact, a notable study involving 6,500 women over 12 years revealed that participants following such a diet had a 20% lower chance of developing depression.

5 Worst foods for mental health

These five inflammatory foods are the most frequent offenders for people with depression:

1. Gluten

Gluten is a protein found in wheat and products such as:

  • White and whole wheat flour
  • Bread, pasta, and pizza dough
  • Crackers, cereals, packaged cookies, and other processed foods
  • Grains like barley, rye, and couscous
  • Many condiments, such as soy sauce

“Gluten-containing foods may trigger inflammation, especially in some individuals who have sensitivities to it, potentially worsening symptoms of depression and anxiety,” Gervacio says.

Gluten prompts gut cells to produce zonulin, a protein that regulates intestinal permeability, resulting in “leaky gut” and inflammation. And beyond depression, it’s been linked to over 200 different conditions, including seizures, headaches, anxiety, ADHD symptoms, and even neurotoxicity.

So, if you suffer from depression or other conditions related to the gut-brain connection, consider removing gluten from your diet to see how you feel.

2. Dairy

Most of us love dairy products. And science can explain why: they contain compounds that trigger the brain’s opioid receptors, meaning they induce a pleasurable experience–which you can even become mildly addicted to.

Numerous studies have also highlighted casein, a predominant protein in dairy, as a potential inflammation trigger. It’s been associated with various psychiatric conditions, including depression and schizophrenia. While dairy may not negatively impact everyone, some do better with alternatives.

If you’re suffering from depression or other mood issues, try going dairy-free for a month.

3. Genetically modified organisms (GMOs)

GMOs have a huge place in the Standard American Diet (SAD). This is worrisome, not just because they’ve been tinkered with at the genetic level, but because they rely heavily on pesticides and herbicides. Some GMOs even produce pesticides on their own.

Many GMO crops are designed to withstand herbicides, especially glyphosate (like in Roundup, which has been linked to cancer and other serious health problems). This means they’re often laden with chemicals meant to eliminate weeds.

“The long-term effects of consuming GMOs are not yet fully understood yet, but there are emerging concerns about its impact on mental health,” Gervacio says. This is partly because these foods can change our gut microbiota–a key player in our overall well-being and mental health.

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Some potential risks of GMOs and heavy pesticide/herbicide consumption include:

  • Altered gut health, impacting mood and mental clarity
  • Impaired production of essential amino acids vital for brain function, such as tryptophan
  • Reduced ability to absorb essential minerals
  • A hindered liver detoxification process, which can impact mood and overall health

Unfortunately, even foods labeled non-GMO aren’t always free from pesticides. So, for those battling mood disorders, opting for organic is a good idea.

4. Sugar

If you have a sweet tooth, you’re not alone. Each year, the average American consumes an astonishing 60 to 100 pounds of sugar. It’s hard to resist, especially when sugar stimulates our brain’s reward system, making us crave more.

But it’s not just cravings that impact your mental health; it’s blood sugar imbalance. “One obvious effect of this is the blood sugar spike and sudden crash, which can cause mood swings and anxiety,” Gervacio says.

“Excessive sugar intake also promotes inflammation,” she adds, which we’ve learned is a major driver of depression. Furthermore, sugar disrupts the gut microbiome and dysregulates hormones, potentially leading to worse mood issues. Keeping your blood sugar levels stable is a great defense against depression.

And artificial sweeteners, unfortunately, aren’t any better. Studies show they also cause hormonal and gut imbalances, and can lead to metabolic issues like insulin resistance.

Gervacio recommends choosing natural sweeteners like honey or maple syrup, and enjoying them in moderation.

5. Vegetable oils

The SAD is loaded with unhealthy fats, primarily in the form of commercial vegetable oils. These oils, often lurking in everyday items like packaged snacks and salad dressings, include:

  • Safflower oil
  • Corn oil
  • Sunflower oil
  • Soybean oil
  • Canola oil

While once touted as healthy options, these oils are typically made from GMOs, utilize intense heating processes, and contain an improper balance of fatty acids.

“Vegetable oils can cause an imbalance of omega 3 and omega 6 fatty acids which may impact brain health,” Gervacio says. “There are some vegetable oils that are high in pro-inflammatory omega-6 fatty acids that can contribute to systemic inflammation.”

Consuming vegetable oils can lead to a myriad of health issues, including:

  • Depression
  • Anxiety
  • Thyroid issues
  • Heart disease
  • Nutrient deficiencies

Try eating healthier, naturally-obtained fats, such as olive, avocado, and coconut oil instead.

So what do I eat instead?

Gervacio recommends doing an “elimination diet” for about four weeks to reset your system.

“During the elimination phase, eat only natural foods, even better with an organic certification seal,” she says. During this time, many people find themselves feeling rejuvenated and notice their preferences shifting towards healthier choices.

Here are Gervacio’s recommended guidelines for the elimination diet and beyond:

  • Opt for high-quality protein sources like poultry, lean, grass-fed beef, and legumes.
  • Load up on organic, non-GMO vegetables such as broccoli, leafy greens, and sweet potatoes.
  • Enjoy organic fruits like apples, pears, and oranges.
  • Incorporate nuts and seeds like almonds, walnuts, and sunflower seeds.
  • Swap processed vegetable oils for healthier alternatives like olive oil, avocado oil, or coconut oil. Enjoy in moderation and as part of a balanced meal.
  • Avoid refined and artificial sugars. Enjoy natural sweeteners like those in fruits, or turn to honey or maple syrup–but use sparingly.
  • Substitute coconut, almond, or oat milk and ghee (clarified, casein-free butter) for traditional dairy products.
  • Choose gluten-free grains such as rice, quinoa, and gluten-free oats.

Changing your diet can feel daunting–especially in a world that promotes quick solutions. But dedicating yourself to better nutrition has profound benefits for your mental and physical health. Choosing anti-inflammatory options in lieu of the worst foods for mental health not only supports a balanced mood, but fine-tunes your understanding of what truly feeds your well-being.

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After your four-week dietary reset, you may consider gradually reintroducing foods, such as dairy. Just pay close attention to how you feel. You might find yourself committed to an anti-inflammatory diet for the long haul.


References:

Impact of Dietary Fats on Brain Functions – PMC

HOW DOES MY BRAIN COMMUNICATE WITH MY BODY? – PMC

Food and mood: how do diet and nutrition affect mental wellbeing? – PMC

Influence of Foods and Nutrition on the Gut Microbiome and Implications for Intestinal Health – PMC

The Impact of Diet and Lifestyle on Gut Microbiota and Human Health – PMC

The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans – PMC

Leaky Gut and the Ingredients That Help Treat It: A Review – PMC

The Gut-Brain Axis: The Missing Link in Depression – PMC

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II – contemporary contextual research – PMC

The Role of Inflammation in Depression and Fatigue – PMC

So depression is an inflammatory disease, but where does the inflammation come from? – PMC

Anti-Inflammatory Dietary Diversity and Depressive Symptoms among Older Adults: A Nationwide Cross-Sectional Analysis – PMC.

Dietary inflammatory potential and the incidence of depression and anxiety: a meta-analysis – PMC

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The effect of the Standard American Diet on Iba-1 immunoreactivity in the spinal cord before and after peripheral inflammatory injury in rats – ScienceDirect

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Dietary wheat gluten induces astro‐ and microgliosis in the hypothalamus of male mice – Rizwan – 2023 – Journal of Neuroendocrinology – Wiley Online Library

The Role of Endoscopy in the Diagnosis of Celiac Disease – PMC

Gluten, Inflammation, and Neurodegeneration – PMC

All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases

Psychiatric and Neurological Manifestations of Celiac Disease in Adults – PMC

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Prevalence of migraine in patients with celiac disease and inflammatory bowel disease

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Gluten, Inflammation, and Neurodegeneration – PMC

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Liver Illness and Psychiatric Patients – PMC

Food-Derived Opioid Peptides in Human Health: A Review – PMC

Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study | Nutrition Journal

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Association between bovine casein antibody and new onset schizophrenia among US military personnel).

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Fermented dairy foods consumption and depressive symptoms: A meta-analysis of cohort studies – PMC

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Genetically Modified Crops and Food Security – PMC

Impacts of genetically engineered crops on pesticide use in the U.S. — the first sixteen years | Environmental Sciences Europe

Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence – ScienceDirect

Glyphosate Test Results

The evidence of human exposure to glyphosate: a review

Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies

Roundup causes embryonic development failure and alters metabolic pathways and gut microbiota functionality in non-target species | Microbiome.

Does Glyphosate Affect the Human Microbiota? – PMC

Perturbations of Amino Acid Metabolism Associated with Glyphosate-Dependent Inhibition of Shikimic Acid Metabolism Affect Cellular Redox Homeostasis and Alter the Abundance of Proteins Involved in Photosynthesis and Photorespiration – PMC.

Glyphosate based-herbicide disrupts energy metabolism and activates inflammatory response through oxidative stress in mice liver – ScienceDirect

Genetically modified foods: safety, risks and public concerns—a review – PMC.

Evaluation of adverse effects/events of genetically modified food consumption: a systematic review of animal and human studies | Environmental Sciences Europe

A Systematic Review of Organic Versus Conventional Food Consumption: Is There a Measurable Benefit on Human Health?

How much sugar is too much? | American Heart Association

Americans eat too much sugar — nearly 100 pounds of sugar and sweeteners each year.

Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake – PMC

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Sugar rush or sugar crash? A meta-analysis of carbohydrate effects on mood

Hypoglycemia: The neglected complication – PMC

Total sugar intake is associated with higher prevalence of depressive symptoms in obese adults.

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High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats – PMC

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History of Canola Seed Development

Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis | Open Heart

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The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials

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